Avandia

Avandia
has been linked to very serious heart problems when taken with insulin. Avandia is produced by GlaxoSmithKline and was first approved by the Food and Drug Administration in 1999 to treat type II, or adult onset diabetes, Avandia quickly became one of the most popular drugs for the company GlaxoSmithKline.

The FDA Safety Alert warns that patients who are taking Avandia (rosiglitazone) - especially those who are known to have underlying heart disease or who are at high risk of heart attack (myocardial infarction) - should speak to their physicians about their continued use of Avandia.

The findings of a study, which will appear in the June 14, 2007 issue of the New England Journal of Medicine. In this study researchers evaluated forty-two (42) separate studies comparing patients using Avandia (rosiglitazone) to patients who were not using Avandia. This study concludes that patients taking Avandia (rosiglitazone) face a 43% increased risk of heart attack, and a 64% increased risk of dying from heart related ( cardiovascular) disease.

Serious Side Effects
Avandia has specifically been linked to serious heart problems when taken along with insulin. Such problems include heart attacks, cardiovascular disease and congestive heart failure caused by Avandia. Read more side effects

Avandia Maker Sued Over Heart Attack

“The widow and son of a Beaumont man are suing the maker of the popular diabetes drug Avandia, alleging it contributed to the man's death from a heart attack. Larry Alan Stanford, 60, died May 21, the same day a scientific analysis was published in the New England Journal of Medicine saying that Avandia was linked to a greater risk of heart attack and possibly death. His widow, Peggie Stanford, and son, Ryan Stanford, filed the lawsuit against GlaxoSmithKline PLC on Tuesday in U.S. District Court for the Eastern District of Texas.”

Associated Press, Forbes 6/20/07

Diabetes Drugs to Receive Strongest Warning

The makers of diabetes drugs Avandia and Actos have agreed to add the most severe warning to inform patients that the medications may increase the risk of heart failure. The Food and Drug Administration said the so called “black box” warnings are separate from concerns that Avandia may increase the risk of heart attacks. A separate FDA review of Avandia and Actos side effects showed cases of significant weight gain and build up of fluids, both risk factors for heat failure. AP, The Washington Post 08/16/2007




Avandia has been linked to very serious heart problems when taken with insulin. Avandia is produced by GlaxoSmithKline and was first approved by the Food and Drug Administration in 1999 to treat type II, or adult onset diabetes, Avandia quickly became one of the most popular drugs for the company GlaxoSmithKline. The FDA Safety Alert warns that patients who are taking Avandia (rosiglitazone) - especially those who are known to have underlying heart disease or who are at high risk of heart attack (myocardial infarction) - should speak to their physicians about their continued use of Avandia. The findings of a study, which will appear in the June 14, 2007 issue of the New England Journal of Medicine. In this study researchers evaluated forty-two (42) separate studies comparing patients using Avandia (rosiglitazone) to patients who were not using Avandia. This study concludes that patients taking Avandia (rosiglitazone) face a 43% increased risk of heart attack, and a 64% increased risk of dying from heart related ( cardiovascular) disease. Serious Side Effects Avandia has specifically been linked to serious heart problems when taken along with insulin. Such problems include heart attacks, cardiovascular disease and congestive heart failure caused by Avandia. Read more side effects Avandia Maker Sued Over Heart Attack “The widow and son of a Beaumont man are suing the maker of the popular diabetes drug Avandia, alleging it contributed to the man's death from a heart attack. Larry Alan Stanford, 60, died May 21, the same day a scientific analysis was published in the New England Journal of Medicine saying that Avandia was linked to a greater risk of heart attack and possibly death. His widow, Peggie Stanford, and son, Ryan Stanford, filed the lawsuit against GlaxoSmithKline PLC on Tuesday in U.S. District Court for the Eastern District of Texas.” Associated Press, Forbes 6/20/07 Diabetes Drugs to Receive Strongest Warning The makers of diabetes drugs Avandia and Actos have agreed to add the most severe warning to inform patients that the medications may increase the risk of heart failure. The Food and Drug Administration said the so called “black box” warnings are separate from concerns that Avandia may increase the risk of heart attacks. A separate FDA review of Avandia and Actos side effects showed cases of significant weight gain and build up of fluids, both risk factors for heat failure. AP, The Washington Post 08/16/2007		Two Diabetes Drugs to Display Strongest Warning The Food and Drug Administration is calling for the makers of Avandia and Actos to carry the most prominent safety warning to alert doctors and patients of potential heart risks. The call for a stronger warning comes more than a year after FDA safety reviewers recommended such steps. The agency made the announcement as officials were questioned as part of a Congressional investigation regarding the delayed warning of heart risks associated with Avandia. Gardiner Harris, The New York Times 06/07/2007 Drug Maker Threatened Lawsuit against Critic A medical expert told lawmakers Wednesday that GlaxoSmithKline executives threatened him with a lawsuit after he drew attention to potential dangers of Avandia in 1999. John Buse, head of endocrinology at the University of North Carolina, told members of Congress that after he raised concerns about potential heart problems associated with Avandia, executives said they intended to hold him responsible for a $4 billion drop in company stock. Matthew Perrone, Forbes 06/06/2007 Experts called study done by Avandia inconclusive at best and a sign of greater risk at worst... read more.
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